Evolution of Susceptibilities of <i>Helicobacter pylori</i> Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study

Eyoum Bille Bertrant; Tali Nguefak Lionel Danny; Fotso Chimi Serge; Malongue Agnes; Ateba Mbassa Roger; Kuiate Jules Roger; Kouitcheu Mabeku Laure Brigitte

doi:doi:10.11648/j.ijg.20200402.17

Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study

Eyoum Bille Bertrant, Tali Nguefak Lionel Danny, Fotso Chimi Serge, Malongue Agnes, Ateba Mbassa Roger, Kuiate Jules Roger, Kouitcheu Mabeku Laure Brigitte

Published in International Journal of Gastroenterology (Volume 4, Issue 2)

Received: 9 October 2020 Accepted: 22 October 2020 Published: 19 November 2020

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Abstract

This study was conducted to estimate the evolution of antimicrobial susceptibilities of H. pylori strains isolated in Cameroon from 2014 to 2016 in relation to sociodemographic factors and clinical outcomes. A total of 278 H. pylori strains were isolated from patients with gastroduodenal disorders and tested for their susceptibility to nine antibiotics using the disc diffusion method. With time, a significant decreased of resistance was observed against clarithromycin (31.11 to 3.20%, p<0.0001), erythromycin (66.69 to 9.6%, p<0.0001) and metronidazole (86.67 to 69.6%, p<0.0001). Resistance to tetracycline (0 to 2.4%) and doxycycline (0 to 1.6%) slightly increase with time. Resistance to amoxicillin (95.5 to 94.4%), ciprofloxacin (4.44 to 4%) and levofloxacin (0 to 0.8%) was relatively constant. No resistance was detected against rifampicin with the time. A significant decrease of resistance was detected against metronidazole / clarithromycin (22.22 to 1.6%, p<0.0001) and amoxicillin / clarithromycin (26.67 to 3.2%, p<0.0001). Among the tested isolates, 0.92 and 2.4% elicited triple resistance to metronidazole / tetracycline / amoxicillin in 2015 and 2016, and 0.8% quadruple resistance to metronidazole / tetracycline / clarithromycin / amoxicillin in 2016. Higher resistance rate was noticed as age increase and among female compared to men. Our data showed evolution in the antimicrobial susceptibilities of H pylori strains circulating in our milieu with time. This finding highlights the need of monitoring periodically H. pylori resistance profile to antibiotics in order to determine the adapted treatment for this infection.

Published in	International Journal of Gastroenterology (Volume 4, Issue 2)
DOI	10.11648/j.ijg.20200402.17
Page(s)	63-71
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Helicobacter pylori, Antibiotics, Resistance Evolution, Cameroon

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APA Style

Eyoum Bille Bertrant, Tali Nguefak Lionel Danny, Fotso Chimi Serge, Malongue Agnes, Ateba Mbassa Roger, et al. (2020). Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study. International Journal of Gastroenterology, 4(2), 63-71. https://doi.org/10.11648/j.ijg.20200402.17

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Eyoum Bille Bertrant; Tali Nguefak Lionel Danny; Fotso Chimi Serge; Malongue Agnes; Ateba Mbassa Roger, et al. Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study. Int. J. Gastroenterol. 2020, 4(2), 63-71. doi: 10.11648/j.ijg.20200402.17

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AMA Style

Eyoum Bille Bertrant, Tali Nguefak Lionel Danny, Fotso Chimi Serge, Malongue Agnes, Ateba Mbassa Roger, et al. Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study. Int J Gastroenterol. 2020;4(2):63-71. doi: 10.11648/j.ijg.20200402.17

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@article{10.11648/j.ijg.20200402.17,
  author = {Eyoum Bille Bertrant and Tali Nguefak Lionel Danny and Fotso Chimi Serge and Malongue Agnes and Ateba Mbassa Roger and Kuiate Jules Roger and Kouitcheu Mabeku Laure Brigitte},
  title = {Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study},
  journal = {International Journal of Gastroenterology},
  volume = {4},
  number = {2},
  pages = {63-71},
  doi = {10.11648/j.ijg.20200402.17},
  url = {https://doi.org/10.11648/j.ijg.20200402.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20200402.17},
  abstract = {This study was conducted to estimate the evolution of antimicrobial susceptibilities of H. pylori strains isolated in Cameroon from 2014 to 2016 in relation to sociodemographic factors and clinical outcomes. A total of 278 H. pylori strains were isolated from patients with gastroduodenal disorders and tested for their susceptibility to nine antibiotics using the disc diffusion method. With time, a significant decreased of resistance was observed against clarithromycin (31.11 to 3.20%, pH pylori strains circulating in our milieu with time. This finding highlights the need of monitoring periodically H. pylori resistance profile to antibiotics in order to determine the adapted treatment for this infection.},
 year = {2020}
}

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TY  - JOUR
T1  - Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study
AU  - Eyoum Bille Bertrant
AU  - Tali Nguefak Lionel Danny
AU  - Fotso Chimi Serge
AU  - Malongue Agnes
AU  - Ateba Mbassa Roger
AU  - Kuiate Jules Roger
AU  - Kouitcheu Mabeku Laure Brigitte
Y1  - 2020/11/19
PY  - 2020
N1  - https://doi.org/10.11648/j.ijg.20200402.17
DO  - 10.11648/j.ijg.20200402.17
T2  - International Journal of Gastroenterology
JF  - International Journal of Gastroenterology
JO  - International Journal of Gastroenterology
SP  - 63
EP  - 71
PB  - Science Publishing Group
SN  - 2640-169X
UR  - https://doi.org/10.11648/j.ijg.20200402.17
AB  - This study was conducted to estimate the evolution of antimicrobial susceptibilities of H. pylori strains isolated in Cameroon from 2014 to 2016 in relation to sociodemographic factors and clinical outcomes. A total of 278 H. pylori strains were isolated from patients with gastroduodenal disorders and tested for their susceptibility to nine antibiotics using the disc diffusion method. With time, a significant decreased of resistance was observed against clarithromycin (31.11 to 3.20%, pH pylori strains circulating in our milieu with time. This finding highlights the need of monitoring periodically H. pylori resistance profile to antibiotics in order to determine the adapted treatment for this infection.
VL  - 4
IS  - 2
ER  -

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Author Information

Eyoum Bille Bertrant

Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Tali Nguefak Lionel Danny

Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Fotso Chimi Serge

Department of Diagnosis and Treatment Support, Laquintinie Hospital Douala, Douala, Cameroon
Malongue Agnes

Department of Internal Medicine, General Hospital Douala, Douala, Cameroon
Ateba Mbassa Roger

Department of Diagnosis and Treatment Support, Laquintinie Hospital Douala, Douala, Cameroon
Kuiate Jules Roger

Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Kouitcheu Mabeku Laure Brigitte

Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon

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APA Style

Eyoum Bille Bertrant, Tali Nguefak Lionel Danny, Fotso Chimi Serge, Malongue Agnes, Ateba Mbassa Roger, et al. (2020). Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study. International Journal of Gastroenterology, 4(2), 63-71. https://doi.org/10.11648/j.ijg.20200402.17

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ACS Style

Eyoum Bille Bertrant; Tali Nguefak Lionel Danny; Fotso Chimi Serge; Malongue Agnes; Ateba Mbassa Roger, et al. Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study. Int. J. Gastroenterol. 2020, 4(2), 63-71. doi: 10.11648/j.ijg.20200402.17

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AMA Style

Eyoum Bille Bertrant, Tali Nguefak Lionel Danny, Fotso Chimi Serge, Malongue Agnes, Ateba Mbassa Roger, et al. Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study. Int J Gastroenterol. 2020;4(2):63-71. doi: 10.11648/j.ijg.20200402.17

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@article{10.11648/j.ijg.20200402.17,
  author = {Eyoum Bille Bertrant and Tali Nguefak Lionel Danny and Fotso Chimi Serge and Malongue Agnes and Ateba Mbassa Roger and Kuiate Jules Roger and Kouitcheu Mabeku Laure Brigitte},
  title = {Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study},
  journal = {International Journal of Gastroenterology},
  volume = {4},
  number = {2},
  pages = {63-71},
  doi = {10.11648/j.ijg.20200402.17},
  url = {https://doi.org/10.11648/j.ijg.20200402.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20200402.17},
  abstract = {This study was conducted to estimate the evolution of antimicrobial susceptibilities of H. pylori strains isolated in Cameroon from 2014 to 2016 in relation to sociodemographic factors and clinical outcomes. A total of 278 H. pylori strains were isolated from patients with gastroduodenal disorders and tested for their susceptibility to nine antibiotics using the disc diffusion method. With time, a significant decreased of resistance was observed against clarithromycin (31.11 to 3.20%, pH pylori strains circulating in our milieu with time. This finding highlights the need of monitoring periodically H. pylori resistance profile to antibiotics in order to determine the adapted treatment for this infection.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Evolution of Susceptibilities of Helicobacter pylori Strains Circulating in Cameroon to Usual Antibiotics: A Three-year Study
AU  - Eyoum Bille Bertrant
AU  - Tali Nguefak Lionel Danny
AU  - Fotso Chimi Serge
AU  - Malongue Agnes
AU  - Ateba Mbassa Roger
AU  - Kuiate Jules Roger
AU  - Kouitcheu Mabeku Laure Brigitte
Y1  - 2020/11/19
PY  - 2020
N1  - https://doi.org/10.11648/j.ijg.20200402.17
DO  - 10.11648/j.ijg.20200402.17
T2  - International Journal of Gastroenterology
JF  - International Journal of Gastroenterology
JO  - International Journal of Gastroenterology
SP  - 63
EP  - 71
PB  - Science Publishing Group
SN  - 2640-169X
UR  - https://doi.org/10.11648/j.ijg.20200402.17
AB  - This study was conducted to estimate the evolution of antimicrobial susceptibilities of H. pylori strains isolated in Cameroon from 2014 to 2016 in relation to sociodemographic factors and clinical outcomes. A total of 278 H. pylori strains were isolated from patients with gastroduodenal disorders and tested for their susceptibility to nine antibiotics using the disc diffusion method. With time, a significant decreased of resistance was observed against clarithromycin (31.11 to 3.20%, pH pylori strains circulating in our milieu with time. This finding highlights the need of monitoring periodically H. pylori resistance profile to antibiotics in order to determine the adapted treatment for this infection.
VL  - 4
IS  - 2
ER  -

Copy | Download