Volume 2, Issue 2, December 2018, Page: 24-27
Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution
Dennis Oju Allagoa, Department of Gynecology and Obstetrics, Federal Medical Centre Yenagoa, Bayelsa state, Nigeria
Benjamin Onyema Eledo, Department of Medical Laboratory Science, Faculty of Health Sciences, Madonna University, Elele, Nigeria; Haematology and Blood Transfusion Department Federal Medical Centre, Yenagoa, Nigeria
Kingsley Excel Dunga, Department of Medical Laboratory Science, Faculty of Health Sciences, Madonna University, Elele, Nigeria
Sylvester Chibueze Izah, Department of Biological Sciences, Faculty of Science, Niger Delta University, Wilberforce Island, Nigeria
Received: Sep. 22, 2018;       Accepted: Oct. 5, 2018;       Published: Nov. 7, 2018
DOI: 10.11648/j.ijg.20180202.11      View  68      Downloads  6
Abstract
This study evaluated the effect of Helicobacter pylori infection on total white blood cells and cluster of differentiation 4 (CD4) cells of students in a Nigerian tertiary educational institution. A total of 32 test subjects (comprising of 17 females and 15 males) and 30 control subjects (comprising of 16 females and 14 males) within the age of 18 – 32. The blood samples of the participants were analyzed for CD4 cells and total white blood cells counts using standard protocols. Results revealed that test and control subjects had mean values of 8.89 ×109/L and 7.13 ×109/L respectively (for females) and 9.12 ×109/L and 7.25 ×109/L respectively (for males) (total white blood cells), and 1369.76 cells/µl and 2169.55 cells/µl respectively for females and 1424.47 cells/µl and 2069.15 cells/µl respectively for males (CD4 counts). Significant variations (p<0.001) exist between test and control subjects for each of the immune system parameters under study. The significant increase in total white blood cells among the test subjects is a result of an immune response to an active infection and subsequent neutrophilia elicited by inflammation which is a major consequence of Helicobacter pylori infection. The decline in CD4 (though within normal range) may suggest that Helicobacter pylori infection may affect the immune system. However, caution should be exercised in the management of the infection especially among individual with other health challenges to avoid adverse health effects.
Keywords
Cluster of Differentiation 4, Helicobacter Pylori, Immune System, Infections, White Blood Cells
To cite this article
Dennis Oju Allagoa, Benjamin Onyema Eledo, Kingsley Excel Dunga, Sylvester Chibueze Izah, Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution, International Journal of Gastroenterology. Vol. 2, No. 2, 2018, pp. 24-27. doi: 10.11648/j.ijg.20180202.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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